MacCHESS Advances: Microcrystallography and More

Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS

The Macromolecular Diffraction Facility at the Cornell High Energy Synchrotron Source (MacCHESS) is a national research resource supported by the National Center for Research Resources of the US National Institutes of Health. MacCHESS is pursuing several research initiatives designed to benefit both CHESS users and the wider structural biology community. Three initiatives are presented in furth...

Development of Low-noise Direct-conversion X-ray Area Detectors for Protein Microcrystallography

Protein microcrystallography using synchrotron radiation

The progress in X-ray microbeam applications using synchrotron radiation is beneficial to structure determination from macromolecular microcrystals such as small in meso crystals. However, the high intensity of microbeams causes severe radiation damage, which worsens both the statistical quality of diffraction data and their resolution, and in the worst cases results in the failure of structure...

Structures from Solutions : Biomolecular Small - Angle Solution Scattering at MacCHESS Richard

Protein crystallography continues to be the prime source of high-resolution molecular structural information in biology. Its success depends totally upon the ability of proteins and other biomolecules to form well-ordered crystalline lattices under the right conditions. Many important biological molecules, however, are not well behaved in this regard, a fact that is becoming more apparent as bi...

D3, the new diffractometer for the macromolecular crystallography beamlines of the Swiss Light Source

A new diffractometer for microcrystallography has been developed for the three macromolecular crystallography beamlines of the Swiss Light Source. Building upon and critically extending previous developments realised for the high-resolution endstations of the two undulator beamlines X06SA and X10SA, as well as the super-bend dipole beamline X06DA, the new diffractometer was designed to the foll...